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1, a deactivated strain of a virus, is ongoing clinical trial for the treatment of metastatic colorectal cancer in Los Angeles (USC/Norris Cancer Center) as well as New York, Washington, D. From 27 February 2002 in USA: Norris Comprehensive Cancer Center and Hospital, Los Angeles, California for the treatment of the patients with IIB, IIC, III, or IV cutaneous melanoma OR stage III or IV ocular or mucosal melanoma is being practiced a vaccinotherapy using Tyrosinase, gp100, and MART-1 peptides together with the alum adjuvant refreshing-stories. Beside this, after the third injections of the vaccine the patients receive radiotherapy- 5 days a week for 5-6 weeks. It is injected endermic, once a week for three weeks, and then switched on to the refreshing-stories back up course- once a month for 2 years.